Odell Beckham Jr., WR -- Beckham Jr. is more than just one famous catch and certainly hasn't fallen victim to the Madden curse. The young receiver is an impressive, productive playmaker who'll challenge the Patriots pass defense all over the field.

Tom Brady, QB -- While Bill Belichick made it clear this week he doesn't care about such matters, No. 12 was everyone's midseason MVP. He's rolling through a great season and this week faces the worst defense, statistically, in the NFL. Should be a big Sunday for Brady, both in terms of real-world points and fantasy points.

Malcolm Butler, CB -- New England's No. 1 corner has seen plenty of impressive opponents this year from Antonio Brown through Desean Jackson. Now, he'll see a lot of fellow second-year player Odell Beckham Jr. in a battle of the guys who made the two most notable plays in the NFL last season.

Cameron Fleming, OL -- It looks like the second-year practice-squad call-up could be the Patriots only healthy tackle for the second-straight Sunday. That could mean more time at left tackle, which he'd never played before last week, protecting Tom Brady's valuable backside. That's called being thrown into the spotlight.

Dont'a Hightower, LB -- With Jamie Collins likely out of action, Hightower will be in the spotlight to test his versatility against the Giants deep corps of backs. New York uses those horses to run the ball, and then Hightower will need to help deal with Shane Vereen's production out of the backfield in the passing game.

Eli Manning, QB -- Forget about Manning's history of beating the Patriots, Peyton's little brother is simply having an impressive season leading the Giants potentially-potent passing attack. He's easily one of the top handful of quarterbacks New England's suspect secondary will face this season.

Brandon Meriweather, S -- The former Patriots first-round pick Meriweather is in the middle of the Giants putrid pass defense. He's a guy that Tom Brady and Rob Gronkowski will clearly look to attack in the passing game.

Jason Pierre-Paul, DE -- The Giants best pass rusher with 12.5 sacks last season before his offseason fireworks accident, Pierre-Paul is expected to add a boost to a New York front that hasn't been able to get to the quarterback this fall. The world is also watching to see if the man they call JPP can return to form given the limitations of his right hand.

Shane Vereen, RB -- Vereen has found a new home in the New York offense. The versatile back leads a crew of Giants backfield playmakers and he'll challenge the Patriots safeties and linebackers in the underneath passing game.