The New England Patriots take on the Buffalo Bills in a regular season game at New Era Field on Sunday, October 30, 2016.
New England Patriots quarterback Tom Brady walks toard the field before an NFL football game against the Buffalo Bills Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Bill Wippert)
New England Patriots quarterbacks Tom Brady (12) and Jimmy Garoppolo (10) head to the field before an NFL football game against the Buffalo Bills Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Bill Wippert)
New England Patriots wide receiver Julian Edelman (11) walks toward the field with teammates before an NFL football game against the Buffalo Bills Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Bill Wippert)
New England Patriots wide receiver Danny Amendola (80) runs on the field with teammates before an NFL football game against the Buffalo Bills at New Era Stadium Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Bill Wippert)
New England Patriots owner Robert Kraft walks toward the field before an NFL football game against the Buffalo Bills Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Bill Wippert)
Former Buffalo Bills quarterback Jim Kelly, left, talks to New England Patriots quarterback Tom Brady before an NFL football game Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Bill Wippert)
New England Patriots tight end Rob Gronkowski (87) runs on the field before an NFL football game against the Buffalo Bills Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Bill Wippert)
New England Patriots helmets are arranged on the sidelines during the first half of an NFL football game against the Buffalo Bills Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Bill Wippert)
New England Patriots quarterback Tom Brady (12) throws a pass to Danny Amendola for a touchdown during the first half of an NFL football game against the Buffalo Bills Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Buffalo Bills cornerback Stephon Gilmore (24) forces New England Patriots' Chris Hogan (15) out of bounds during the first half of an NFL football game Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Bill Wippert)
New England Patriots wide receiver Chris Hogan (15) runs away from Buffalo Bills' Stephon Gilmore (24) for a touchdown during the first half of an NFL football game Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
New England Patriots wide receiver Chris Hogan (15) runs away from Buffalo Bills' Stephon Gilmore (24) for a touchdown during the first half of an NFL football game Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Buffalo Bills wide receiver Brandon Tate (15) celebrates after scoring a touchdown during the first half of an NFL football game against the Buffalo Bills Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
New England Patriots wide receiver Chris Hogan (15) celebrates after scoring a touchdown during the first half of an NFL football game against the Buffalo Bills Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
New England Patriots' Chris Hogan (15) celebrates after scoring a touchdown during the first half of an NFL football game against the Buffalo Bills Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Bill Wippert)
New England Patriots tight end Rob Gronkowski, right, hugs Chris Hogan after Hogan scored a touchdown during the first half of an NFL football game against the Buffalo Bills Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Bill Wippert)
The Buffalo Bills play the New England Patriots during the first half of an NFL football game Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Bill Wippert)
New England Patriots tight end Rob Gronkowski (87) catches a pass in front of Buffalo Bills' Nickell Robey-Coleman (21) during the first half of an NFL football game Sunday, Oct. 30, 2016, in Orchard Park, N.Y. Gronkowski scored a touchdown on the play. (AP Photo/Adrian Kraus)
New England Patriots celebrate a touchdown by Rob Gronkowski (87) during the first half of an NFL football game against the Buffalo Bills Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Bill Wippert)
New England Patriots tight end Rob Gronkowski (87) runs away from Buffalo Bills' Nickell Robey-Coleman (21) for a touchdown during the first half of an NFL football game Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Bill Wippert)
New England Patriots' Rob Ninkovich (50) tackles Buffalo Bills' Jerome Felton (42) during the first half of an NFL football game Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Bill Wippert)
New England Patriots' Julian Edelman (11) celebrates with LeGarrette Blount (29) after scoring a touchdown during the second half of an NFL football game against the Buffalo Bills Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Bill Wippert)
Buffalo Bills inside linebacker Preston Brown (52) watches as New England Patriots' Julian Edelman (11) stretches the ball across the goal line for a touchdown during the second half of an NFL football game Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Bill Wippert)
Buffalo Bills quarterback Tyrod Taylor (5) runs for a touchdown during the second half of an NFL football game against the New England Patriots Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Bill Wippert)
New England Patriots quarterback Tom Brady (12) throws a pass to Rob Gronkowski for a touchdown during the first half of an NFL football game Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
New England Patriots quarterback Tom Brady (12), Rob Gronkowski (87) and James Develin (46) head back to their side line after LeGarrette Blount scored a touchdown during the second half of an NFL football game against the Buffalo Bills Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Bill Wippert)
New England Patriots quarterback Tom Brady (12) rushes past Buffalo Bills' Stephon Gilmore (24) and Nickell Robey-Coleman (21) during the second half of an NFL football game Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
New England Patriots' LeGarrette Blount rushes for a touchdown during the second half of an NFL football game against the Buffalo Bills Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Bill Wippert)
Buffalo Bills inside linebacker Preston Brown (52) sacks New England Patriots' James White (28) during the second half of an NFL football game Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Bill Wippert)
New England Patriots' Rob Gronkowski (87) celebrates after LeGarrette Blount scored a touchdown during the second half of an NFL football game against the Buffalo Bills Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Bill Wippert)
New England Patriots' LeGarrette Blount (29) dives for a touchdown during the second half of an NFL football game Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Buffalo Bills running back Mike Gillislee (35) runs for a touchdown during the first half of an NFL football game against the New England Patriots Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
New England Patriots wide receiver Danny Amendola (80) runs after making a catch during the second half of an NFL football game Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Buffalo Bills defensive tackle Marcell Dareus (99) fights off a block during the second half of an NFL football game against the New England Patriots Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Bill Wippert)
New England Patriots' LeGarrette Blount (29) rushes during the second half of an NFL football game against the Buffalo Bills Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Bill Wippert)
Buffalo Bills quarterback Tyrod Taylor (5) breaks a tackle by New England Patriots' Rob Ninkovich (50) during the second half of an NFL football game Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
New England Patriots' Julian Edelman (11) runs after making a catch during the second half of an NFL football game against the Buffalo Bills Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
New England Patriots quarterback Tom Brady (12) smiles during the second half of an NFL football game against the Buffalo Bills Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Bill Wippert)
New England Patriots free safety Duron Harmon (30) tackles Buffalo Bills' Mike Gillislee (35) during the first half of an NFL football game Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
New England Patriots' Tom Brady (12) throws a pass as Joe Thuney (62) blocks Buffalo Bills' Leger Douzable (91) during the second half of an NFL football game Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
Buffalo Bills inside linebacker Zach Brown (53) sacks New England Patriots' Jimmy Garoppolo (10) during the second half of an NFL football game Sunday, Oct. 30, 2016, in Orchard Park, N.Y. The Patriots win 41-25. (AP Photo/Adrian Kraus)
New England Patriots kicker Stephen Gostkowski (3) reacts after kicking a field goal during the first half of an NFL football game against the Buffalo Bills Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Bill Wippert)
Buffalo Bills head coach Rex Ryan, left, shakes hands with New England Patriots head coach Bill Belichick, right, after an NFL football game Sunday, Oct. 30, 2016, in Orchard Park, N.Y. The Patriots win 41-25. (AP Photo/Adrian Kraus)
Buffalo Bills head coach Rex Ryan, right, and New England Patriots head coach Bill Belichick shake hands after an NFL football game Sunday, Oct. 30, 2016, in Orchard Park, N.Y. The Patriots win 41-25. (AP Photo/Bill Wippert)
New England Patriots' Danny Amendola (80) returns a kickoff during the second half of an NFL football game against the Buffalo Bills Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Bill Wippert)
New England Patriots' Rob Gronkowski (87) gestures to fans after an NFL football game against the Buffalo Bills Sunday, Oct. 30, 2016, in Orchard Park, N.Y. The Patriots win 41-25. (AP Photo/Bill Wippert)
New England Patriots' Devin McCourty (32) defends a pass to Buffalo Bills' Charles Clay (85) during the first half of an NFL football game Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
New England Patriots head coach Bill Belichick walks on the sidelines during the second half of an NFL football game against the Buffalo Bills Sunday, Oct. 30, 2016, in Orchard Park, N.Y. The Patriots win 41-25. (AP Photo/Bill Wippert)
Buffalo Bills' Reggie Bush (22) runs past New England Patriots' Shea McClellin (58) during the first half of an NFL football game Sunday, Oct. 30, 2016, in Orchard Park, N.Y. (AP Photo/Adrian Kraus)
New England Patriots tight end Rob Gronkowski (87) waves to fans after an NFL football game against the Buffalo Bills Sunday, Oct. 30, 2016, in Orchard Park, N.Y. The Patriots won 41-25. (AP Photo/Bill Wippert)
ORCHARD PARK, N.Y. (AP) --Patriots quarterback Tom Brady asserted his on-field ownership of the Buffalo Bills again Sunday, matching an NFL record in beating them for the 26th time.
Brady went 22 of 33 for 315 yards and threw four touchdowns in leading New England to a 41-25 win. He improved to 26-3 against Buffalo , matching a record set by Brett Favre, who went 26-9 against Detroit.
Best of all, Brady's performance had Bills fans heading for the exits early in the fourth quarter, what whatever Patriots fans remained as the clock wound down.
"We've had a lot of experiences where there's 70,000 people against you," Brady said. "And at the end there's 5,000 Patriots (fans) on the road that are cheering for us. ... To be so far ahead you can run out the clock, it's a great feeling."
The Patriots (7-1) have won four straight since Brady returned after opening the season serving the NFL's four-game "Deflategate" suspension. His absence included New England's only blemish, a 16-0 home loss to Buffalo on Oct. 2, the first time the Patriots were shut out at home since 1993.
And don't think that loss didn't still sting.
"You know, they like to talk all that. They got that win," said tight end Rob Gronkowski, who had 109 yards receiving and a touchdown. "I'm so glad we came in here and showed them what we're really about."
After a Bills field goal, Brady threw touchdowns passes on his first two drives. They included a 53-yarder to former Bills receiver Chris Hogan , who beat cornerback Stephon Gilmore up the left sideline.
The Patriots then broke the game open by scoring 27 points over five consecutive possessions in a surge that began with Gronkowski scoring his 69th career touchdown to break a franchise record previously held by Stanley Morgan.
The Bills (4-4) sputtered minus their offensive top threat, running back LeSean McCoy, who has a hamstring injury. And their defense was unable to keep the Patriots in check despite star defensive tackle Marcell Dareus making his season debut.
Dareus missed the past three games because a hamstring injury, and missed the start of the season serving a four-game suspension for violating the NFL's substance abuse policy.
"Obviously, we weren't good enough," Bills coach Rex Ryan said. "We made way too many mistakes, mistakes that we haven't made all season. And against a guy like Brady, he makes you pay."
The Patriots punted just three times and converted nine of 13 third-down opportunities.
Backup running back Mike Gillislee scored on a 3-yard run and Taylor scrambled for a 26-yard touchdown on fourth down in the third quarter. Jonathan Williams scored on a 1-yard run with 30 seconds left.
Danny Amendola and Julian Edelman also caught touchdown passes, while LeGarrette Blount scored on a 1-yard run.
For Brady, it was his first four-TD outing since a 36-7 win over Miami last October. It was the most he's had on the road since throwing four in a 37-22 win at Orchard Park on Oct. 12, 2014.
Of his 20 regular-season games with four touchdowns passing or more, six have been against Buffalo.
GRONK MILESTONE
Gronkowski, who grew up in Buffalo, actually set two franchise records with his 53-yard touchdown catch . It was his 69th touchdown and 68th TD receiving, moving him one ahead of Morgan in both categories.
After spiking the ball, Gronkowski spun and took a bow.
He said he bowed in tribute to his mother, Diane, who met with Gronkowski at the team hotel on Saturday and told him how proud she would be for him to break the record.
"I was like, I've got to give her a shoutout for letting me know she's super proud of me," he said. "Hi mom and thank you."
SACK ATTACK
The Bills had five sacks, upping their season total to 26 - five more than they managed all last season. Veteran defensive tackle Kyle Williams had one, his 38th, moving into eighth on the franchise list, one ahead of Sherman White.
SPECIAL TEAMS
Patriots: Amendola's 73-yard kickoff return to open the second half led to Brady's 12-yard TD pass to Edelman to put New England up 31-10.
Bills: Bills punter Colton Schmidt bumbled his drop while facing fourth-and-15 at his own 20. He quickly scooped it up and broke up the right sideline for a 16-yard gain. Buffalo eventually went on to score on Taylor's 26-yard run to cut the Patriots lead to 31-17 midway through the third quarter.
INJURIES
Patriots: None reported.
Bills: LB Lorenzo Alexander did not return after hurting one of his hamstrings during a punt return in the second quarter. Receiver Brandon Tate (concussion protocol) did not return after being tackled by Devin McCourty in the third quarter. RB Reggie Bush hurt his groin.
