FOXBOROUGH, Mass. (AP) -- Tom Brady called out Rex Ryan and then he beat the Bills - again.
After shouting the name of the Buffalo coach as an audible, Brady led New England to a 20-13 victory over the Bills on Monday night and kept the defending Super Bowl champions on course for their second perfect regular season in nine years.
Brady completed 20 of 39 passes for 277 yards, hitting James White for a 20-yard score that was the first touchdown of the running back's career. White added a 6-yard run in the third quarter to give New England (10-0) the lead for good.
Buffalo's LeSean McCoy ran 20 times for 82 yards and a 27-yard touchdown and caught six passes for 41 yards to surpass 100 yards from scrimmage for the fourth straight game. The Bills (5-5) snapped a two-game winning streak and lost to Brady for the 25th time in 28 games.
The game was filled with mistakes, penalties, injuries and turnovers - including two fumbles on a single punt, a rare missed field goal by Stephen Gostkowski and an inadvertent whistle that led to one of many lengthy conferences among the officials.
And New England lost another key player: Danny Amendola, who took over as the Patriots' No. 1 receiver because of last week's injury to Julian Edelman, caught nine passes for 117 yards before leaving with a knee injury of his own in the third quarter.
With the wind chill temperature at 21 degrees at kickoff, both teams struggled on offense, and the Patriots even failed to score in the fourth - the first time they were shut out in a quarter since the first one of the season.
In the third quarter, both teams fumbled on the same punt.
Leodis McKelvin fielded a punt at his own 30 yard-line and made it just 2 yards before the ball was knocked out by Brandon King. New England's Jonathan Freeny picked up the ball and rumbled 5 yards before he lost the ball and it bounced out of bounds.
The Patriots took over at the Buffalo 30 and took a 20-10 lead on Gostkowski's 35-yard field goal.
Even the referees were sloppy.
Early in the third, Brady rolled toward the right sideline before throwing downfield to Amendola. As the receiver broke for the end zone, the play was whistled dead - apparently because the official thought Brady stepped out of bounds.
After a lengthy discussion, the referee announced that there was an inadvertent whistle. The 14-yard reception counted, with a 15-yard penalty for interference from the Bills coaching staff. The drive ended with an even more unusual error: Gostkowski's first miss in 51 weeks.
Brady threw a first-half interception that was nullified by offsetting penalties. But he did throw one at the Buffalo goal line in the fourth that stuck.
Brady took a dig at Ryan in the first quarter by adding "Rex Ryan!" to his pre-snap signals. The Bills coach has been a longtime rival of the Patriots.
But the Patriots managed just a field goal in the first, then went scoreless for 22 minutes, 16 seconds before Brady led a 33-second touchdown drive to make it 10-3 with 13 seconds left in the half.
Brady threw an out pass to White, who broke a tackle along the sideline to score from 20 yards out.
That prolonged New England's scoring streak, but it came to an end at 38 in a row when they failed to score in the fourth.
And another streak was snapped, too.
Gostkowski hadn't missed a kick all season, a total of 22 field goals and 35 extra points before his attempt from 54 yards out in the third quarter sailed wide right. It was his first miss since Nov. 30, 2014, and his first miss at home since Week 2 of the 2013 season.
NOTES:Brady improved to 11-4 in his career against teams coached by Ryan. ... McCoy is the first Buffalo player to rush for more than 100 yards in four consecutive games since C.J. Spiller in 2012. ... Patriots injuries: Amendola (knee) and WR Aaron Dobson (ankle). Bills injuries: WR Marcus Easley (head), OL John Miller (ankle), S Bacarri Rambo (shoulder), DL Mario Williams (foot), TE Charles Clay (neck). ... Gostkowski extended his streak of consecutive extra points to 447.
View a collection of the best images from the Patriots regular season game against the Buffalo Bills at Gillette Stadium on Monday, November 23, 2015.
Fans arrive for an NFL football game between the New England Patriots and the Buffalo Bills, Monday, Nov. 23, 2015, in Foxborough, Mass. (AP Photo/Steven Senne)
The Hall of Names, the place where the names of the Holocaust victims are permanently preserved.
The Hall of Names, the place where the names of the Holocaust victims are permanently preserved.
New England Patriots head coach Bill Belichick looks on before an NFL football game against the Buffalo Bills, Monday, Nov. 23, 2015, in Foxborough, Mass. (AP Photo/Charles Krupa)
Buffalo Bills head coach Rex Ryan walks onto the field before an NFL football game against the New England Patriots, Monday, Nov. 23, 2015, in Foxborough, Mass. (AP Photo/Steven Senne)
Mayor of Isreal Nir Barkat, Robert Kraft, Jonathan Kraft, Dan Kraft and Josh Kraft look on during opening ceremonies of the Kraft Famly Sports Campus grand opening.
Mayor of Isreal Nir Barkat, Robert Kraft, Jonathan Kraft, Dan Kraft and Josh Kraft look on during opening ceremonies of the Kraft Famly Sports Campus grand opening.
Robert Kraft introduces Jim Brown and Nir Barkat, the Mayor of Israel, who spoke to the Hall of Famers during dinner at St Andrew's Church.
Robert Kraft introduces Jim Brown and Nir Barkat, the Mayor of Israel, who spoke to the Hall of Famers during dinner at St Andrew's Church.
New England Patriots quarterback Tom Brady gets pumped up before an NFL football game against the Buffalo Bills, Monday, Nov. 23, 2015, in Foxborough, Mass. (AP Photo/Charles Krupa)
New England Patriots quarterback Tom Brady gets pumped up before an NFL football game against the Buffalo Bills, Monday, Nov. 23, 2015, in Foxborough, Mass. (AP Photo/Charles Krupa)
New England Patriots quarterback Tom Brady gets pumped up before an NFL football game against the Buffalo Bills, Monday, Nov. 23, 2015, in Foxborough, Mass. (AP Photo/Charles Krupa)
New England Patriots owner Robert Kraft pats New England Patriots quarterback Tom Brady (12) as he leaves the field after warmups before an NFL football game against the Buffalo Bills, Monday, Nov. 23, 2015, in Foxborough, Mass. (AP Photo/Charles Krupa)
Robert Kraft is presented with an honorary plaque by Israel Mayor Nir Barkat.
Robert Kraft is presented with an honorary plaque by Israel Mayor Nir Barkat.
Fireworks light the sky before an NFL football game between the New England Patriots and the Buffalo Bills, Monday, Nov. 23, 2015, in Foxborough, Mass. (AP Photo/Charles Krupa)
Joe Montana and Robert Kraft at the Kraft Family Sports Campus.
Joe Montana and Robert Kraft at the Kraft Family Sports Campus.
Fans observe a moment of silence for Ezra Schwartz, killed in the West Bank last week, before an NFL football game between the New England Patriots and the Buffalo Bills, Monday, Nov. 23, 2015, in Foxborough, Mass. (AP Photo/Charles Krupa)
New England Patriots head coach Bill Belichick, center, and others observe a moment of silence for Ezra Schwartz, who was killed in the West Bank last week, before an NFL football game against the Buffalo Bills, Monday, Nov. 23, 2015, in Foxborough, Mass. (AP Photo/Steven Senne)
New England Patriots defensive end Dominique Easley (99) hits Buffalo Bills quarterback Tyrod Taylor, left, as he releases a pass in the first half of an NFL football game Monday, Nov. 23, 2015, in Foxborough, Mass. (AP Photo/Charles Krupa)
New England Patriots quarterback Tom Brady (12) passes against the Buffalo Bills in the first half of an NFL football game, Monday, Nov. 23, 2015, in Foxborough, Mass. (AP Photo/Charles Krupa)
Buffalo Bills safety Leodis McKelvin, back, tackles New England Patriots wide receiver Danny Amendola (80) after a catch in the first half of an NFL football game Monday, Nov. 23, 2015, in Foxborough, Mass. (AP Photo/Charles Krupa)
New England Patriots quarterback Tom Brady (12) calls signals at the line of scrimmage in the first half of an NFL football game against the Buffalo Bills, Monday, Nov. 23, 2015, in Foxborough, Mass. (AP Photo/Charles Krupa)
New England Patriots kicker Stephen Gostkowski (3) kicks a field goal against the Buffalo Bills in the first half of an NFL football game, Monday, Nov. 23, 2015, in Foxborough, Mass. (AP Photo/Steven Senne)
New England Patriots fans stand bundled against the cold weather before an NFL football game between the Patriots and the Buffalo Bills, Monday, Nov. 23, 2015, in Foxborough, Mass. (AP Photo/Steven Senne)
Buffalo Bills quarterback Tyrod Taylor, second from right, scrambles away from New England Patriots defensive lineman Jabaal Sheard (93) in the first half of an NFL football game Monday, Nov. 23, 2015, in Foxborough, Mass. (AP Photo/Charles Krupa)
New England Patriots head coach Bill Belichick talks to his team on the sideline in the first half of an NFL football game against the Buffalo Bills, Monday, Nov. 23, 2015, in Foxborough, Mass. (AP Photo/Charles Krupa)
New England Patriots head coach Bill Belichick uses a tablet device on the sideline in the first half of an NFL football game against the Buffalo Bills, Monday, Nov. 23, 2015, in Foxborough, Mass. (AP Photo/Charles Krupa)
New England Patriots defensive end Rob Ninkovich (50) tries to knock down a pass by Buffalo Bills quarterback Tyrod Taylor (5) in the first half of an NFL football game, Monday, Nov. 23, 2015, in Foxborough, Mass. (AP Photo/Charles Krupa)
Buffalo Bills safety Bacarri Rambo (30) soars over New England Patriots wide receiver Aaron Dobson (17) after he caught a pass and was brought down by Bills defensive back Ronald Darby (28) in the first half of an NFL football game, Monday, Nov. 23, 2015, in Foxborough, Mass. (AP Photo/Charles Krupa)
New England Patriots fans hold signs and photos referring to Buffalo Bills head coach Rex Ryan in the first half of an NFL football game Monday, Nov. 23, 2015, in Foxborough, Mass. (AP Photo/Steven Senne)
New England Patriots quarterback Tom Brady (12) hands off to running back Brandon Bolden (38) in the first half of an NFL football game against the Buffalo Bills, Monday, Nov. 23, 2015, in Foxborough, Mass. (AP Photo/Charles Krupa)
New England Patriots wide receiver Aaron Dobson (17) catches a pass with Buffalo Bills defensive back Ronald Darby (28) hanging onto him in the first half of an NFL football game, Monday, Nov. 23, 2015, in Foxborough, Mass. (AP Photo/Charles Krupa)
New England Patriots running back James White (28) scores a touchdown as teammate Danny Amendola (80) celebrates in the first half of an NFL football game against the Buffalo Bills, Monday, Nov. 23, 2015, in Foxborough, Mass. (AP Photo/Charles Krupa)
New England Patriots wide receiver Aaron Dobson (17) is helped to the sideline after an injury in the first half of an NFL football game against the Buffalo Bills, Monday, Nov. 23, 2015, in Foxborough, Mass. (AP Photo/Steven Senne)
New England Patriots fans hold a picture and sign referring to Patriots quarterback Tom Brady in the first half of an NFL football game against the Buffalo Bills, Monday, Nov. 23, 2015, in Foxborough, Mass. (AP Photo/Charles Krupa)
New England Patriots running back James White (28) pulls free from Buffalo Bills safety Corey Graham (20) on his way to a touchdown in the first half of an NFL football game, Monday, Nov. 23, 2015, in Foxborough, Mass. (AP Photo/Steven Senne)
New England Patriots running back James White, center, celebrates his touchdown with wide receiver Danny Amendola (80) in front of Buffalo Bills safety Bacarri Rambo (30) in the first half of an NFL football game, Monday, Nov. 23, 2015, in Foxborough, Mass. (AP Photo/Charles Krupa)
Buffalo Bills defensive back Ronald Darby (28) and New England Patriots Brandon Bolden (38) and Jonathan Freeny (55) chase a loose ball in the second half of an NFL football game, Monday, Nov. 23, 2015, in Foxborough, Mass. (AP Photo/Steven Senne)
New England Patriots tight end Rob Gronkowski (87) tackles Buffalo Bills defensive back Stephon Gilmore (24) after he intercepted a pass in the second half of an NFL football game, Monday, Nov. 23, 2015, in Foxborough, Mass. (AP Photo/Charles Krupa)
New England Patriots head coach Bill Belichick watches from the sideline in the second half of an NFL football game against the Buffalo Bills, Monday, Nov. 23, 2015, in Foxborough, Mass. (AP Photo/Charles Krupa)
New England Patriots wide receiver Chris Harper (14) and Buffalo Bills defensive backs Stephon Gilmore (24) and Corey Graham (20) contend for a pass in the second half of an NFL football game, Monday, Nov. 23, 2015, in Foxborough, Mass. Gilmore intercepted it. (AP Photo/Charles Krupa) `
New England Patriots fans interact with mascot Pat Patriot in the second half of an NFL football game against the Buffalo Bills, Monday, Nov. 23, 2015, in Foxborough, Mass. (AP Photo/Steven Senne)
New England Patriots quarterback Tom Brady (12) passes against the Buffalo Bills in the second half of an NFL football game, Monday, Nov. 23, 2015, in Foxborough, Mass. (AP Photo/Steven Senne)
New England Patriots offensive coordinator Josh McDaniels celebrates a touchdown with guard Josh Kline (67) in the second half of an NFL football game against the Buffalo Bills, Monday, Nov. 23, 2015, in Foxborough, Mass. (AP Photo/Charles Krupa)
Julian Edelman – Instagram (@edelman11): Tony Hawk Pro Skater: Mexico City
Julian Edelman – Instagram (@edelman11): Tony Hawk Pro Skater: Mexico City
Brooks Ellis – Instagram (@brooksellis51): The crew for Dead and Company
Brooks Ellis – Instagram (@brooksellis51): The crew for Dead and Company
Malcolm Mitchell – Instagram (@money_mitch26): Best of Both Worlds!!
Malcolm Mitchell – Instagram (@money_mitch26): Best of Both Worlds!!
Julian Edelman – Instagram (@edelman11): Had a great day today hanging in Hanover, of course gotta love reading for the kids. Last year I got to read to this particular class, this year I was able to introduce my own book, Flying High. It was an awesome experience #fordakids#flyinghigh
Julian Edelman – Instagram (@edelman11): Had a great day today hanging in Hanover, of course gotta love reading for the kids. Last year I got to read to this particular class, this year I was able to introduce my own book, Flying High. It was an awesome experience #fordakids#flyinghigh
Duron Harmon – Instagram (@dharm30): Just wanna say congrats to @martellusb and @siggib on celebrating their 6th year anniversary and appreciate you, for allowing me and the wifey to celebrate it with you guys! #celebratingsix#Myguyhadwhitewalkers #superrich#hadmyvalryiansteelontuck
Duron Harmon – Instagram (@dharm30): Just wanna say congrats to @martellusb and @siggib on celebrating their 6th year anniversary and appreciate you, for allowing me and the wifey to celebrate it with you guys! #celebratingsix#Myguyhadwhitewalkers #superrich#hadmyvalryiansteelontuck
Marcus Cannon – Instagram (@marcuscannon61): Just fishin'
Marcus Cannon – Instagram (@marcuscannon61): Just fishin'
Woodrow Hamilton – Instagram (@sanctified_iammm): @valeria3000
Woodrow Hamilton – Instagram (@sanctified_iammm): @valeria3000
Stephon Gilmore – Instagram (@bumpnrungilmore): In the Yayo wit it‼
Stephon Gilmore – Instagram (@bumpnrungilmore): In the Yayo wit it‼
Matt Lengel – Instagram (@matthewlengel): And again...Â
Matt Lengel – Instagram (@matthewlengel): And again...Â
