- The New England first offense and defensive units started the game and played through the majority of the first quarter which accounted for two series each.
- For the fourth straight week first-round pick CB Devin McCourty and second-round pick LB Brandon Spikes started on defense.
- RB Thomas Clayton's 55-yard kickoff return in the first quarter is the Patriots fourth return of 50 or more yards in the 2010 preseason. Rookie CB Devin McCourty had a 52 yard return and a 50 yard return in the first preseason game vs. New Orleans (8/12).WR Brandon Tate opened the St. Louis game (8/26) with a 97-yard kickoff return for a touchdown.
- QB Tom Brady started and played the entire first quarter, finishing 4-of-8 for 51 yards with one touchdown and one interception. On his first drive of the game, he led the Patriots on an 8-play, 45-yard drive that was culminated with a 5-yard touchdown pass to TE Rob Gronkowski.
- Rookie TE Rob Gronkowski caught a five-yard touchdown pass from QB Tom Brady in the first quarter. It marks his fourth touchdown of the preseason. He finished with two touchdowns vs. St. Louis (8/26) and one vs. Atlanta (8/19).
- Backup QB Brian Hoyer entered the game in the second quarter and finished 15-of26 for 266 yards with one touchdown and one interception.
- Hoyer completed two 60-yard passes. In the third quarter he connected with WR Rod Owens for a 67-yard pass reception and then connected with WR Darnell Jenkins for a 66-yard touchdown in the fourth quarter.
- The Patriots had three 60-yard pass plays in the 2010 preseason with two from Hoyer and then a 65-yard touchdown pass from Tom Brady to Randy Moss vs. St. Louis (8/26).
- WR Darnell Jenkins led the team with five receptions for 93 yards against the Giants.
- WR Brandon Tate started at wide receiver against the Giants. Tate started one of the two games he played as a rookie in 2009, starting vs. Miami (11/8) when the Patriots opened in a four-wide receiver set.
- Rich Ohrnberger started at right guard in place of Stephen Neal.
- Rookie WR Buddy Farnham, the Ivy League Player of the Year at Brown as a wide receiver, played on defense and broke up a Giants pass in the end zone in the third quarter. He finished the game with four total tackles and two passes defensed.
- K Stephen Gostkowski connected on a 46-yard field goal in the second quarter. Entering 2010, his 85.1 percent accuracy rate is the highest in Patriots history.
- LB Tyrone McKenzie led the team with 10 total tackles.
